Study of PARP inhibitors for breast cancer based on enhanced multiple kernel function SVR with PSO

• Asıl Yazarlar: Haohan Xue (Yazar), Ruixuan Zhang (Yazar), Xudong Yan (Yazar), Ruihan Wang (Yazar), Peijian Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

PARP1 is one of six enzymes required for the highly error-prone DNA repair pathway microhomology-mediated end joining (MMEJ) and needs to be inhibited when over-expressed. In order to study the PARP1 inhibitory effect of fused tetracyclic or pentacyclic dihydrodiazepinoindolone derivatives (FTPDDs)...