Study of PARP inhibitors for breast cancer based on enhanced multiple kernel function SVR with PSO

• Main Authors: Haohan Xue (Author), Ruixuan Zhang (Author), Xudong Yan (Author), Ruihan Wang (Author), Peijian Zhang (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

PARP1 is one of six enzymes required for the highly error-prone DNA repair pathway microhomology-mediated end joining (MMEJ) and needs to be inhibited when over-expressed. In order to study the PARP1 inhibitory effect of fused tetracyclic or pentacyclic dihydrodiazepinoindolone derivatives (FTPDDs)...