SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration

• मुख्य लेखकों: Zhen-Zhen Guo (लेखक), Qun-An Cao (लेखक), Zong-Zhuang Li (लेखक), Li-Ping Liu (लेखक), Zhi Zhang (लेखक), Ya-Juan Zhu (लेखक), Guang Chu (लेखक), Qiu-Yan Dai (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2016-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Nicotine, a major chemical component of cigarettes, plays a pivotal role in the development of abdominal aortic aneurysm (AAA). c-Jun N-terminal kinase (JNK) has been demonstrated to participate in elastase-induced AAA. This study aimed to elucidate whether the JNK inhibitor SP600125 can attenuate n...