SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration

• Autori principali: Zhen-Zhen Guo (Autore), Qun-An Cao (Autore), Zong-Zhuang Li (Autore), Li-Ping Liu (Autore), Zhi Zhang (Autore), Ya-Juan Zhu (Autore), Guang Chu (Autore), Qiu-Yan Dai (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2016-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Nicotine, a major chemical component of cigarettes, plays a pivotal role in the development of abdominal aortic aneurysm (AAA). c-Jun N-terminal kinase (JNK) has been demonstrated to participate in elastase-induced AAA. This study aimed to elucidate whether the JNK inhibitor SP600125 can attenuate n...