Role of P-Glycoprotein Expression and Function in Cystinotic Renal Proximal Tubular Cells

Role of P-Glycoprotein Expression and Function in Cystinotic Renal Proximal Tubular Cells

P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine. Studies in mice deficient in P-gp showed generaliz...

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Main Authors: Joost P. Schoeber (Author), Elena Levtchenko (Author), Lambertus P. van den Heuvel (Author), Dorien Reijnders (Author), Martijn J. Wilmer (Author), Karen Peeters (Author), Rosalinde Masereeuw (Author)
Format: Book
Published: MDPI AG, 2011-10-01T00:00:00Z.
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3rd Floor Main Library

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