Role of P-Glycoprotein Expression and Function in Cystinotic Renal Proximal Tubular Cells

• Main Authors: Joost P. Schoeber (Author), Elena Levtchenko (Author), Lambertus P. van den Heuvel (Author), Dorien Reijnders (Author), Martijn J. Wilmer (Author), Karen Peeters (Author), Rosalinde Masereeuw (Author)
• Format: Book
• Published: MDPI AG, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine. Studies in mice deficient in P-gp showed generaliz...