Role of P-Glycoprotein Expression and Function in Cystinotic Renal Proximal Tubular Cells

• Главные авторы: Joost P. Schoeber (Автор), Elena Levtchenko (Автор), Lambertus P. van den Heuvel (Автор), Dorien Reijnders (Автор), Martijn J. Wilmer (Автор), Karen Peeters (Автор), Rosalinde Masereeuw (Автор)
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• Опубликовано: MDPI AG, 2011-10-01T00:00:00Z.
• Предметы: article
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P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine. Studies in mice deficient in P-gp showed generaliz...