Role of P-Glycoprotein Expression and Function in Cystinotic Renal Proximal Tubular Cells

• Autori principali: Joost P. Schoeber (Autore), Elena Levtchenko (Autore), Lambertus P. van den Heuvel (Autore), Dorien Reijnders (Autore), Martijn J. Wilmer (Autore), Karen Peeters (Autore), Rosalinde Masereeuw (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2011-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine. Studies in mice deficient in P-gp showed generaliz...