Molecular Dynamics Study of Human MTHFR Wild-Type and A222V Mutant-Type: A Computational Approach

• Главные авторы: Michael Resta Surya Yanuar (Автор), Dita Maria Virginia (Автор), Enade Perdana Istyastono (Автор)
• Формат: ‌
• Опубликовано: Universitas Sanata Dharma, 2023-05-01T00:00:00Z.
• Предметы: article
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Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for the homeostasis and metabolism of intracellular folate. However, it is known that one of the commonly found MTHFR gene SNPs (A222V) causes a decrease in activity which decreases folate levels and increases the accumulation of hom...