Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway

AbstractIn this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (serotonin, 5-HT)1A receptor (5-HT1AR) was undertak...

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Main Authors: Hao Zhou (Author), Mengjiao Li (Author), Hui Liu (Author), Zheng Liu (Author), Xuekun Wang (Author), Shiben Wang (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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3rd Floor Main Library

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