Repurposing Synthetic Congeners of a Natural Product Aurone Unveils a Lead Antitumor Agent Inhibiting Folded P-Loop Conformation of MET Receptor Tyrosine Kinase

• Main Authors: Ahmed H. E. Hassan (Author), Cai Yi Wang (Author), Cheol Jung Lee (Author), Hye Rim Jeon (Author), Yeonwoo Choi (Author), Suyeon Moon (Author), Chae Hyeon Lee (Author), Yeon Ju Kim (Author), Soo Bin Cho (Author), Kazem Mahmoud (Author), Selwan M. El-Sayed (Author), Sang Kook Lee (Author), Yong Sup Lee (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A library of 24 congeners of the natural product sulfuretin were evaluated against nine panels representing nine cancer diseases. While sulfuretin elicited very weak activities at 10 µM concentration, congener <b>1t</b> was identified as a potential compound triggering growth inhibition...