Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides

• Hoofdauteurs: Guido Tomás Rozenblum (Auteur), Tomás Kaufman (Auteur), Alfredo Daniel Vitullo (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Aptamer ligands for myelin basic protein (MBP) were obtained using the systematic evolution of ligand by exponential enrichment (SELEX) method. Two clones were isolated from a pool of oligonucleotides and tested for MBP targeting. Using purified MBP, we demonstrated the binding activity of the aptam...