Loading Dose of Ceftazidime Needs to Be Increased in Critically Ill Patients: A Retrospective Study to Evaluate Recommended Loading Dose with Pharmacokinetic Modelling

• Glavni autori: Manon Launay (Autor), Edouard Ollier (Autor), Benjamin Kably (Autor), Félicien Le Louedec (Autor), Guillaume Thiery (Autor), Julien Lanoiselée (Autor), Sophie Perinel-Ragey (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2024-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

To rapidly achieve ceftazidime target concentrations, a 2 g loading dose (LD) is recommended before continuous infusion, but its adequacy in critically ill patients, given their unique pharmacokinetics, needs investigation. This study included patients from six ICUs in Saint-Etienne and Paris, Franc...