Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• প্রধান লেখক: Qian Zhou (লেখক), Meiling Le (লেখক), Yiyi Yang (লেখক), Wenjuan Wang (লেখক), Yuqi Huang (লেখক), Quan Wang (লেখক), Yijing Tian (লেখক), Meiyan Jiang (লেখক), Yong Rao (লেখক), Hai-Bin Luo (লেখক), Yinuo Wu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...