Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Prif Awduron: Qian Zhou (Awdur), Meiling Le (Awdur), Yiyi Yang (Awdur), Wenjuan Wang (Awdur), Yuqi Huang (Awdur), Quan Wang (Awdur), Yijing Tian (Awdur), Meiyan Jiang (Awdur), Yong Rao (Awdur), Hai-Bin Luo (Awdur), Yinuo Wu (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2023-03-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...