Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Asıl Yazarlar: Qian Zhou (Yazar), Meiling Le (Yazar), Yiyi Yang (Yazar), Wenjuan Wang (Yazar), Yuqi Huang (Yazar), Quan Wang (Yazar), Yijing Tian (Yazar), Meiyan Jiang (Yazar), Yong Rao (Yazar), Hai-Bin Luo (Yazar), Yinuo Wu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...