Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Автори: Qian Zhou (Автор), Meiling Le (Автор), Yiyi Yang (Автор), Wenjuan Wang (Автор), Yuqi Huang (Автор), Quan Wang (Автор), Yijing Tian (Автор), Meiyan Jiang (Автор), Yong Rao (Автор), Hai-Bin Luo (Автор), Yinuo Wu (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...