The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway

• Main Authors: Hajer Tlili (Author), Anca Macovei (Author), Daniela Buonocore (Author), Manuela Lanzafame (Author), Hanen Najjaa (Author), Anita Lombardi (Author), Andrea Pagano (Author), Maurizia Dossena (Author), Manuela Verri (Author), Abdelkarim Ben Arfa (Author), Mohamed Neffati (Author), Enrico Doria (Author)
• Format: Book
• Published: BMC, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hyperactivation of mechanistic target of rapamycin (mTOR) signaling pathway is involved in the regulation of cellular growth, proliferation, and more in general, is a common phenomenon in most types of cancers. Thus, natural substances targeting this pathway can be of great thera...