Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry

• المؤلفون الرئيسيون: Jing Xu (مؤلف), John E. Coughlin (مؤلف), Malgorzata Szyjka (مؤلف), Serene Jabary (مؤلف), Sonal Saluja (مؤلف), Zoran Sosic (مؤلف), Yunqiu Chen (مؤلف), Chong-Feng Xu (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

ABSTRACTAggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. So far, investigational efforts have primarily focused on understanding the causes and effec...