Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry

• Main Authors: Jing Xu (Author), John E. Coughlin (Author), Malgorzata Szyjka (Author), Serene Jabary (Author), Sonal Saluja (Author), Zoran Sosic (Author), Yunqiu Chen (Author), Chong-Feng Xu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. So far, investigational efforts have primarily focused on understanding the causes and effec...