Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry

• Autors principals: Jing Xu (Autor), John E. Coughlin (Autor), Malgorzata Szyjka (Autor), Serene Jabary (Autor), Sonal Saluja (Autor), Zoran Sosic (Autor), Yunqiu Chen (Autor), Chong-Feng Xu (Autor)
• Format: Llibre
• Publicat: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

ABSTRACTAggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. So far, investigational efforts have primarily focused on understanding the causes and effec...