CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages

• Main Authors: Yisong Qian (Author), Chuqiao Chen (Author), Leliang Ma (Author), Ziwei Wang (Author), Ling-Fang Wang (Author), Li Zuo (Author), Yaqin Yang (Author), Xiang Huang (Author), Meixiu Jiang (Author), Xiaolei Wang (Author), Huidong Shi (Author), Mingui Fu (Author), Ke-Yu Deng (Author), Hong-Bo Xin (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. Here, we showed the downregulations of both TLR2 mRNA and protein in m...