Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP

• Main Authors: Hayato Yabe (Author), Mohammed Emamussalehin Choudhury (Author), Madoka Kubo (Author), Noriko Nishikawa (Author), Masahiro Nagai (Author), Masahiro Nomoto (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The effect of zonisamide, an antiepileptic agent with anti-parkinsonian effects, was studied on dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 mice and common marmosets. Groups of mice (n = 8 - 9) were treated with: MPTP (15 mg/kg every 2 h ×4); MPTP p...