Temperature Dependence of the Complexation Mechanism of Celecoxib and Hydroxyl-β-cyclodextrin in Aqueous Solution

• Главные авторы: Po-Chiang Chiang (Автор), Yue Shi (Автор), Yong Cui (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2014-08-01T00:00:00Z.
• Предметы: article
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Hydroxypropyl-β-cyclodextrin (HP-β-CD) is commonly used as a complexation reagent to solubilize compounds with poor aqueous solubility to improve in vivo dosing. However, the degree of solubility enhancement was often limited by the formation of only a 1:1 complex and a low complexation constant (K)...