Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice

• Main Authors: Kouichi Yamamoto (Author), Naoko Kureyama (Author), Keiko Asano (Author), Toshiji Ikeda (Author), Atsushi Yamatodani (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994,...