Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry

Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry

Biotherapeutic's higher order structure (HOS) is a critical determinant of its functional properties and conformational relevance. Here, we evaluated two covalent labeling methods: diethylpyrocarbonate (DEPC)-labeling and fast photooxidation of proteins (FPOP), in conjunction with mass spectrom...

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Main Authors: Arnik Shah (Author), Dipanwita Batabyal (Author), Dayong Qiu (Author), Weidong Cui (Author), John Harrahy (Author), Alexander R. Ivanov (Author)
Format: Book
Published: Elsevier, 2024-08-01T00:00:00Z.
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