Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

• Main Authors: Xiaojie Ma (Author), Xiaowu Dong (Author), Yao Xu (Author), Nan Ma (Author), Mei Wei (Author), Xiaochun Xie (Author), Yingying Lu (Author), Wangsen Cao (Author), Guotao Lu (Author), Weiqin Li (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined. Here, we observed a marked reduction in acinar GPX4 expression and ferroptotic cell death in mice wi...