Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

• Κύριοι συγγραφείς: Xiaojie Ma (Συγγραφέας), Xiaowu Dong (Συγγραφέας), Yao Xu (Συγγραφέας), Nan Ma (Συγγραφέας), Mei Wei (Συγγραφέας), Xiaochun Xie (Συγγραφέας), Yingying Lu (Συγγραφέας), Wangsen Cao (Συγγραφέας), Guotao Lu (Συγγραφέας), Weiqin Li (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2022-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined. Here, we observed a marked reduction in acinar GPX4 expression and ferroptotic cell death in mice wi...