Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis

• Główni autorzy: Xiaojie Ma (Autor), Xiaowu Dong (Autor), Yao Xu (Autor), Nan Ma (Autor), Mei Wei (Autor), Xiaochun Xie (Autor), Yingying Lu (Autor), Wangsen Cao (Autor), Guotao Lu (Autor), Weiqin Li (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Glutathione peroxidase 4 (GPX4)-dependent ferroptosis in pancreatic acinar cells plays a critical role in acute pancreatitis (AP). However, potential upstream regulators of GPX4 are not well defined. Here, we observed a marked reduction in acinar GPX4 expression and ferroptotic cell death in mice wi...