Selective COX-2 Inhibitors: Road from Success to Controversy and the Quest for Repurposing

• Main Authors: Afaf A. El-Malah (Author), Magdy M. Gineinah (Author), Pran Kishore Deb (Author), Ahdab N. Khayyat (Author), Monika Bansal (Author), Katharigatta N. Venugopala (Author), Anfal S. Aljahdali (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The introduction of selective COX-2 inhibitors (so-called 'coxibs') has demonstrated tremendous commercial success due to their claimed lower potential of serious gastrointestinal adverse effects than traditional NSAIDs. However, following the repeated questioning on safety concerns, the c...