Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling

• Главные авторы: Patricia Oliveros-Matus (Автор), Nelson Perez-Urrutia (Автор), Nathalie Alvarez-Ricartes (Автор), Florencia Echeverria (Автор), George E. Barreto (Автор), James Elliott (Автор), Alexandre Iarkov (Автор), Valentina Echeverria (Автор)
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• Опубликовано: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Предметы: article
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Fear memory extinction (FE) is an important therapeutic goal for Posttraumatic stress disorder (PTSD). Cotinine facilitates FE in rodents, in part due to its inhibitory effect on the amygdala by the glutamatergic projections from the medial prefrontal cortex (mPFC). The cellular and behavioral effec...