Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling

• Main Authors: Patricia Oliveros-Matus (Author), Nelson Perez-Urrutia (Author), Nathalie Alvarez-Ricartes (Author), Florencia Echeverria (Author), George E. Barreto (Author), James Elliott (Author), Alexandre Iarkov (Author), Valentina Echeverria (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fear memory extinction (FE) is an important therapeutic goal for Posttraumatic stress disorder (PTSD). Cotinine facilitates FE in rodents, in part due to its inhibitory effect on the amygdala by the glutamatergic projections from the medial prefrontal cortex (mPFC). The cellular and behavioral effec...