Compatibility and Fidelity of Mirror-Image Thymidine in Transcription Events by T7 RNA Polymerase

• Asıl Yazarlar: Qingju Liu (Yazar), Yongqi Ke (Yazar), Yuhe Kan (Yazar), Xinjing Tang (Yazar), Xiangjun Li (Yazar), Yujian He (Yazar), Li Wu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2020-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Due to highly enzymatic d-stereoselectivity, l-nucleotides (l-2'-deoxynucleoside 5'-triphosphates [l-dNTPs]) are not natural targets of polymerases. In this study, we synthesized series of l-thymidine (l-T)-modified DNA strands and evaluated the processivity of nucleotide incorporation for...