Compatibility and Fidelity of Mirror-Image Thymidine in Transcription Events by T7 RNA Polymerase

• मुख्य लेखकों: Qingju Liu (लेखक), Yongqi Ke (लेखक), Yuhe Kan (लेखक), Xinjing Tang (लेखक), Xiangjun Li (लेखक), Yujian He (लेखक), Li Wu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Due to highly enzymatic d-stereoselectivity, l-nucleotides (l-2'-deoxynucleoside 5'-triphosphates [l-dNTPs]) are not natural targets of polymerases. In this study, we synthesized series of l-thymidine (l-T)-modified DNA strands and evaluated the processivity of nucleotide incorporation for...