Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Targeted drug conjugates based on Affibody molecules fused to an albumin-binding domain (ABD) for half-life extension have demonstrated potent anti-tumor activity in preclinical therapeutic studies. Furthermore, optimization of their molecular design might increase the cytotoxic effect on tumors and...

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Main Authors: Tianqi Xu (Author), Jie Zhang (Author), Maryam Oroujeni (Author), Maria S. Tretyakova (Author), Vitalina Bodenko (Author), Mikhail V. Belousov (Author), Anna Orlova (Author), Vladimir Tolmachev (Author), Anzhelika Vorobyeva (Author), Torbjörn Gräslund (Author)
Format: Book
Published: MDPI AG, 2022-02-01T00:00:00Z.
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3rd Floor Main Library

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