Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

• Hlavní autoři: Tianqi Xu (Autor), Jie Zhang (Autor), Maryam Oroujeni (Autor), Maria S. Tretyakova (Autor), Vitalina Bodenko (Autor), Mikhail V. Belousov (Autor), Anna Orlova (Autor), Vladimir Tolmachev (Autor), Anzhelika Vorobyeva (Autor), Torbjörn Gräslund (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2022-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Targeted drug conjugates based on Affibody molecules fused to an albumin-binding domain (ABD) for half-life extension have demonstrated potent anti-tumor activity in preclinical therapeutic studies. Furthermore, optimization of their molecular design might increase the cytotoxic effect on tumors and...