Physiologically based absorption modeling to predict the bioequivalence of two cilostazol formulations

• Main Authors: Lu Wang (Author), Pengfei Zhao (Author), Ting Luo (Author), Dandan Yang (Author), Qianqian Jiang (Author), Jinliang Chen (Author), Honggang Lou (Author), Zourong Ruan (Author), Bo Jiang (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In vivo pharmacokinetic simulations and virtual bioequivalence (BE) evaluation of cilostazol have not yet been described for humans. Here, we successfully developed a physiologically based absorption model to simulate plasma concentrations of cilostazol. In addition, virtual population simu...