Physiologically based absorption modeling to predict the bioequivalence of two cilostazol formulations

• Glavni autori: Lu Wang (Autor), Pengfei Zhao (Autor), Ting Luo (Autor), Dandan Yang (Autor), Qianqian Jiang (Autor), Jinliang Chen (Autor), Honggang Lou (Autor), Zourong Ruan (Autor), Bo Jiang (Autor)
• Format: Knjiga
• Izdano: Wiley, 2023-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract In vivo pharmacokinetic simulations and virtual bioequivalence (BE) evaluation of cilostazol have not yet been described for humans. Here, we successfully developed a physiologically based absorption model to simulate plasma concentrations of cilostazol. In addition, virtual population simu...