Diminished CD40L expression on T-cells in a case of disseminated cryptococcosis

• Main Authors: Supreet Kumar Mohanty (Author), Deepshi Thakral (Author), Devika Gupta (Author), Prabin Kumar (Author), Dipendra Kumar Mitra (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

X-linked hyperimmunoglobulin M (HIGM) syndrome may increase the susceptibility of patients to disseminated cryptococcal infections primarily due to CD40L deficiency that causes defective cross talk between T- and B-cells, thus preventing class switching. In HIGM syndrome, serum IgM levels are elevat...