The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

• Main Authors: Makoto Ishikawa (Author), Toru Nakazawa (Author), Hiroshi Kunikata (Author), Kota Sato (Author), Takeshi Yoshitomi (Author), Kathiresan Krishnan (Author), Douglas F. Covey (Author), Charles F. Zorumski (Author), Yukitoshi Izumi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely inactive at GABA receptors, offers similar neuroprote...