The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

• প্রধান লেখক: Makoto Ishikawa (Author), Toru Nakazawa (Author), Hiroshi Kunikata (Author), Kota Sato (Author), Takeshi Yoshitomi (Author), Kathiresan Krishnan (Author), Douglas F. Covey (Author), Charles F. Zorumski (Author), Yukitoshi Izumi (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely inactive at GABA receptors, offers similar neuroprote...