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Synthesis and Biological Evaluation of RGD-Cryptophycin Conjugates for Targeted Drug Delivery

Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR) cancer cells. Because of neurotoxic side effects and limited efficacy in vivo, cryptophycin-52 failed as a clinical candidate in cancer treatmen...

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Main Authors: Adina Borbély (Author), Eduard Figueras (Author), Ana Martins (Author), Simone Esposito (Author), Giulio Auciello (Author), Edith Monteagudo (Author), Annalise Di Marco (Author), Vincenzo Summa (Author), Paola Cordella (Author), Raffaella Perego (Author), Isabell Kemker (Author), Marcel Frese (Author), Paola Gallinari (Author), Christian Steinkühler (Author), Norbert Sewald (Author)
Format: Book
Published: MDPI AG, 2019-04-01T00:00:00Z.
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