DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer's disease (AD). To inhibit ODC, α-difluoromethylornithine (DFMO), an irreversible ODC inhibitor, has been widely used. However, due to its poor phar...
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| Format: | Book |
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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