Mitotic crossover promotes leukemogenesis in children born with TEL-AML1 via the generation of loss of heterozygosity at 12p

• Asıl Yazarlar: Ivan Ivanovski (Yazar), Livia Garavelli (Yazar), Olivera Djurić (Yazar), Aleksandar Ćirović (Yazar), Dejan Škorić (Yazar), Petar I. Ivanovski (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: PAGEPress Publications, 2015-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

TEL-AML1 (ETV6-RUNX1) fusion gene which is formed prenatally in 1% of the newborns, is a common genetic abnormality in childhood Bcell precursor acute lymphoblastic leukemia. But only one child out of a hundred children born with this fusion gene develops leukemia (bottleneck phenomenon) later in it...