Mitotic crossover promotes leukemogenesis in children born with TEL-AML1 via the generation of loss of heterozygosity at 12p

• Main Authors: Ivan Ivanovski (Author), Livia Garavelli (Author), Olivera Djurić (Author), Aleksandar Ćirović (Author), Dejan Škorić (Author), Petar I. Ivanovski (Author)
• Format: Book
• Published: PAGEPress Publications, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TEL-AML1 (ETV6-RUNX1) fusion gene which is formed prenatally in 1% of the newborns, is a common genetic abnormality in childhood Bcell precursor acute lymphoblastic leukemia. But only one child out of a hundred children born with this fusion gene develops leukemia (bottleneck phenomenon) later in it...