Mitotic crossover promotes leukemogenesis in children born with TEL-AML1 via the generation of loss of heterozygosity at 12p

• Päätekijät: Ivan Ivanovski (Tekijä), Livia Garavelli (Tekijä), Olivera Djurić (Tekijä), Aleksandar Ćirović (Tekijä), Dejan Škorić (Tekijä), Petar I. Ivanovski (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: PAGEPress Publications, 2015-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

TEL-AML1 (ETV6-RUNX1) fusion gene which is formed prenatally in 1% of the newborns, is a common genetic abnormality in childhood Bcell precursor acute lymphoblastic leukemia. But only one child out of a hundred children born with this fusion gene develops leukemia (bottleneck phenomenon) later in it...