Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

• Үндсэн зохиолчид: Jorge C. Correia (Зохиогч), Julie Massart (Зохиогч), Jan Freark de Boer (Зохиогч), Margareta Porsmyr-Palmertz (Зохиогч), Vicente Martínez-Redondo (Зохиогч), Leandro Z. Agudelo (Зохиогч), Indranil Sinha (Зохиогч), David Meierhofer (Зохиогч), Vera Ribeiro (Зохиогч), Marie Björnholm (Зохиогч), Sascha Sauer (Зохиогч), Karin Dahlman-Wright (Зохиогч), Juleen R. Zierath (Зохиогч), Albert K. Groen (Зохиогч), Jorge L. Ruas (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2015-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. Methods: We expressed each FXR variant in primary hepatocytes and evaluate...