Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

• Main Authors: Jorge C. Correia (Author), Julie Massart (Author), Jan Freark de Boer (Author), Margareta Porsmyr-Palmertz (Author), Vicente Martínez-Redondo (Author), Leandro Z. Agudelo (Author), Indranil Sinha (Author), David Meierhofer (Author), Vera Ribeiro (Author), Marie Björnholm (Author), Sascha Sauer (Author), Karin Dahlman-Wright (Author), Juleen R. Zierath (Author), Albert K. Groen (Author), Jorge L. Ruas (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. Methods: We expressed each FXR variant in primary hepatocytes and evaluate...