Development and validation of a yeast high-throughput screen for inhibitors of Aβ42 oligomerization
SUMMARY Recent reports point to small soluble oligomers, rather than insoluble fibrils, of amyloid β (Aβ), as the primary toxic species in Alzheimer's disease. Previously, we developed a low-throughput assay in yeast that is capable of detecting small Aβ42 oligomer formation. Specifically, Aβ42...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2011-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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