Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

• Autors principals: Laura Hellinen (Autor), Heidi Hongisto (Autor), Eva Ramsay (Autor), Kai Kaarniranta (Autor), Kati-Sisko Vellonen (Autor), Heli Skottman (Autor), Marika Ruponen (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2020-02-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The retinal pigment epithelial (RPE) cell monolayer forms the outer blood−retinal barrier and has a crucial role in ocular pharmacokinetics. Although several RPE cell models are available, there have been no systematic comparisons of their barrier properties with respect to drug permeabili...