Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

• Main Authors: Laura Hellinen (Author), Heidi Hongisto (Author), Eva Ramsay (Author), Kai Kaarniranta (Author), Kati-Sisko Vellonen (Author), Heli Skottman (Author), Marika Ruponen (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The retinal pigment epithelial (RPE) cell monolayer forms the outer blood−retinal barrier and has a crucial role in ocular pharmacokinetics. Although several RPE cell models are available, there have been no systematic comparisons of their barrier properties with respect to drug permeabili...