The Serotonin Receptor 6 Antagonist Idalopirdine and Acetylcholinesterase Inhibitor Donepezil Have Synergistic Effects on Brain Activity-A Functional MRI Study in the Awake Rat

• Principais autores: Craig F. Ferris (Autor), Praveen Kulkarni (Autor), Jason R. Yee (Autor), Mark Nedelman (Autor), Inge E. M. de Jong (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD) and other CNS disorders. The high-affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetyl...