Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR:LA-Corpulent Rats

• Hauptverfasser: Raylene A. Reimer (VerfasserIn), Jeremy M. LaMothe (VerfasserIn), Ronald F. Zernicke (VerfasserIn)
• Format: Buch
• Veröffentlicht: Hindawi Limited, 2012-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Leptin signaling deficient rodents have emerged as models of obesity/insulin resistance syndrome. Altered leptin signaling, however, can affect axial and appendicular bone geometrical properties differently, and, thus, we hypothesized that leptin-deficiency would differentially influence mechanical...