Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

• Main Authors: Frank S Choveau (Author), Fayal eAbderemane-Ali (Author), Fabien C Coyan (Author), Zeineb eEs- (Author), Isabelle eBaro (Author), Gildas eLoussouarn (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate. S4 segments control the opening of the intracellular a...