Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

• Asıl Yazarlar: Frank S Choveau (Yazar), Fayal eAbderemane-Ali (Yazar), Fabien C Coyan (Yazar), Zeineb eEs- (Yazar), Isabelle eBaro (Yazar), Gildas eLoussouarn (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate. S4 segments control the opening of the intracellular a...