Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

• Auteurs principaux: Frank S Choveau (Auteur), Fayal eAbderemane-Ali (Auteur), Fabien C Coyan (Auteur), Zeineb eEs- (Auteur), Isabelle eBaro (Auteur), Gildas eLoussouarn (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate. S4 segments control the opening of the intracellular a...