Spray-Dried Formulation of Epicertin, a Recombinant Cholera Toxin B Subunit Variant That Induces Mucosal Healing

• Autori principali: Micaela A. Reeves (Autore), Joshua M. Royal (Autore), David A. Morris (Autore), Jessica M. Jurkiewicz (Autore), Nobuyuki Matoba (Autore), Krystal T. Hamorsky (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Epicertin (EPT) is a recombinant variant of the cholera toxin B subunit, modified with a C-terminal KDEL endoplasmic reticulum retention motif. EPT has therapeutic potential for ulcerative colitis treatment. Previously, orally administered EPT demonstrated colon epithelial repair activity in dextran...