Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

• Main Authors: Jakob Schiøler Hansen (Author), Jens Otto Clemmesen (Author), Niels Henry Secher (Author), Miriam Hoene (Author), Andrea Drescher (Author), Cora Weigert (Author), Bente Klarlund Pedersen (Author), Peter Plomgaard (Author)
• Format: Book
• Published: Elsevier, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background & aims: Fibroblast growth factor 21 (FGF-21) is a liver-derived metabolic regulator induced by energy deprivation. However, its regulation in humans is incompletely understood. We addressed the origin and regulation of FGF-21 secretion in humans. Methods: By determination of arterial-...